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Susceptibility testing not recommended as the species is a poor target for therapy with the medicinal product.

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Clotrimazole in the form of a troche (lozenge) is now considered to be the antifungal of choice to treat oral Candida infections in patients who are immunocompromised, including those with HIV infections.

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When MOE goes unrecognized and untreated, the infection continues to smolder and over weeks or months can spread deeper into the head and involve the bones of the skull base, constituting skull base osteomyelitis (SBO).

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Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

Total dose must be adjusted depending on type of candidal infection being treated.

Candida required an average of 2 doses compared to 3-4 doses in patients infected with other organisms.

Inclusion or absence of a drug label on the AIDS info site does not imply endorsement or lack thereof by AIDS info.

As initial treatment topical agents are used in creams, vaginal tablets and eggs for periods ranging from about 7 to 10 days, the eggs and cream with a cure rate of no more than 75% is achieved.

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Between 1998 and 2000, there has been an approximately fivefold increase in the number of nonmyeloablative transplants; these less intensive conditioning regimens are now used in about 25% of the allogeneic transplants in some institutions ().

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Fluconazole decreases ergosterol synthesis by interfering with cytochrome P450 activity, thus inhibiting cell membrane formation of susceptible fungi including B dermatitidis, Candida spp, C immitis, C neoformans, Epidermophyton spp, H capsulatum, Mycosporum spp, Trichophyton spp, thus leading to cell death.

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Inhibition of this enzyme by azoles causes an accumulation of C 14 methylated sterols which likely disrupt membrane structure ().

Fluconazole is particularly noted for its lack of serious side effects and its compatibility with AZT (before fluconazole, AIDS patients had few if any options for dealing with fungal infections).

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In a randomized trial of episodic vs continuous use of fluconazole to determine which strategy for the prevention and treatment of mucocutaneous candidiasis would more likely lead to refractory candidiasis, no difference was observed in the rates of refractory disease (4.

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Those who have accepted prophylaxis should be offered full STI screening after treatment to exclude the possibility of treatment failure or re-infection if the source of infection was a regular partner.

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